Transporters and drug-drug interactions: important determinants of drug disposition and effects

J König, F Müller, MF Fromm, MC Michel - Pharmacological reviews, 2013 - Elsevier
Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II

SF Zhou - Clinical pharmacokinetics, 2009 - Springer
Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Applications of CYP450 testing in the clinical setting

CF Samer, KI Lorenzini, V Rollason, Y Daali… - Molecular diagnosis & …, 2013 - Springer
Interindividual variability in drug response is a major clinical problem. Polymedication and
genetic polymorphisms modulating drug-metabolising enzyme activities (cytochromes P450 …

Polymorphism of human cytochrome P450 enzymes and its clinical impact

SF Zhou, JP Liu, B Chowbay - Drug metabolism reviews, 2009 - Taylor & Francis
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Renal drug transporters and drug interactions

A Ivanyuk, F Livio, J Biollaz, T Buclin - Clinical pharmacokinetics, 2017 - Springer
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine

M Drozdzik, C Gröer, J Penski, J Lapczuk… - Molecular …, 2014 - ACS Publications
Intestinal transporters are crucial determinants in the oral absorption of many drugs. We
therefore studied the mRNA expression (N= 33) and absolute protein content (N= 10) of …

Expression and function of efflux drug transporters in the intestine

M Takano, R Yumoto, T Murakami - Pharmacology & therapeutics, 2006 - Elsevier
A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs

I Cascorbi - Pharmacology & therapeutics, 2006 - Elsevier
Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor

J Chen, K Raymond - Annals of clinical microbiology and antimicrobials, 2006 - Springer
Rifampicin, an important drug in the treatment of tuberculosis, is used extensively despite its
broad effects on drug-drug interactions, creating serious problems. The clinical importance …

Pharmacogenetics: from bench to byte

JJ Swen, I Wilting, AL De Goede… - Clinical …, 2008 - Wiley Online Library
Despite initial enthusiasm, 1, 2, 3 the use of pharmacogenetics has remained limited to
investigation in only a few clinical fields such as oncology and psychiatry. 4, 5, 6, 7, 8 The …