Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)

HA Younus, M Al-Rashida, A Hameed… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Multicomponent reactions (MCR) has been utilized to synthesize a vast range
of analogs belonging to diverse classes of heterocyclic compounds offering …

[HTML][HTML] Multicomponent reactions for the synthesis of active pharmaceutical ingredients

Á Cores, J Clerigué, E Orocio-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Multicomponent reactions 9i. e., those that engage three or more starting materials to form a
product that contains significant fragments of all of them), have been widely employed in the …

A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives

D He, M Wang, S Zhao, Y Shu, H Zeng, C Xiao, C Lu… - Fitoterapia, 2017 - Elsevier
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …

Synthesis of 1, 2, 3-triazole linked 4 (3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus

S Gatadi, J Gour, M Shukla, G Kaul, S Das… - European Journal of …, 2018 - Elsevier
Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging
global health concern leading to increasing morbidity and mortality. Continuous increase in …

Green synthesis of novel pyridines via one-pot multicomponent reaction and their anti-inflammatory evaluation

HM Abd El-Lateef, AA Abdelhamid, MM Khalaf… - ACS …, 2023 - ACS Publications
A functional and environmentally green procedure for the design of novel pyridine 5a–h and
7a–d derivatives through two pathways is presented. The first pathway is via a one-pot, four …

Sustainable methine sources for the synthesis of heterocycles under metal-and peroxide-free conditions

G ChandruáSenadi, V SuresháKudale - Green Chemistry, 2019 - pubs.rsc.org
Alcohols and ethers were identified as sustainable methine sources for synthesizing
quinazolinone and benzimidazole derivatives using a combination of TsOH· H2O/O2 and …

A micellar catalysis strategy applied to the Pd-catalyzed C–H arylation of indoles in water

GN Vaidya, S Fiske, H Verma, SK Lokhande… - Green …, 2019 - pubs.rsc.org
The selective control over multiple competing C–H sites would enable straightforward
access to functionalized indoles. In this context, we report here a modular and selective C–H …

[HTML][HTML] Multicomponent approach to the synthesis and spectral characterization of some 3, 5-pyrazolididione derivatives and evaluation as anti-inflammatory agents

Y El-Ossaily, N Alanazi, I Althobaiti… - Current Chemistry …, 2024 - m.growingscience.com
Pyrazolones are a class of heterocyclic compounds that contain a pyrazole ring fused to a
ketone group. Recent scientific research has focused extensively on the potential anti …

Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: synthesis of natural products and drugs

SK Ghosh, R Nagarajan - RSC advances, 2016 - pubs.rsc.org
A mild and greener protocol was developed to synthesize substituted quinazolinones and
dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of …