Diagnosis of acute leptospirosis

T Toyokawa, M Ohnishi, N Koizumi - Expert review of anti-infective …, 2011 - Taylor & Francis
Leptospirosis is a globally important zoonotic disease and an important public health
problem in developing countries. Early diagnosis is essential because antibiotic treatment is …

Leptospiral nephropathy

L Andrade, E de Francesco Daher, AC Seguro - Seminars in nephrology, 2008 - Elsevier
Leptospirosis is recognized as a globally re-emerging zoonosis. Interstitial nephritis is the
principal feature of the disease. Leptospirosis-induced acute kidney injury typically is …

In Vitro Identification of Novel Plasminogen-Binding Receptors of the Pathogen Leptospira interrogans

ML Vieira, MV Atzingen, TR Oliveira, R Oliveira… - PloS one, 2010 - journals.plos.org
Background Leptospirosis is a multisystem disease caused by pathogenic strains of the
genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to …

Characterization of Novel OmpA-Like Protein of Leptospira interrogans That Binds Extracellular Matrix Molecules and Plasminogen

R Oliveira, ZM de Morais, AP Gonçales, EC Romero… - PloS one, 2011 - journals.plos.org
Leptospira interrogans is the etiological agent of leptospirosis, a zoonotic disease of human
and veterinary concern. The identification of novel proteins that mediate host-pathogen …

Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity

S Rajapakse, C Rodrigo, SM Handunnetti… - Annals of Clinical …, 2015 - Springer
Leptospirosis is a zoonotic spirochaetal illness that is endemic in many tropical countries.
The research base on leptospirosis is not as strong as other tropical infections such as …

Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV

ML Vieira, ZM de Morais, AP Gonçales, EC Romero… - Journal of Infection, 2010 - Elsevier
Leptospira interrogans is the etiological agent of leptospirosis, a zoonotic disease that
affects populations worldwide. We have identified in proteomic studies a protein that is …

Pathogenic, diagnostic and vaccine potential of leptospiral outer membrane proteins (OMPs)

V Raja, K Natarajaseenivasan - Critical reviews in microbiology, 2015 - Taylor & Francis
Pathogenic Leptospira species are important human and animal pathogen that causes
leptospirosis, with more than half a million cases reported annually but little is known …

Interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis

ML Vieira, ALTO Nascimento - Critical reviews in microbiology, 2016 - Taylor & Francis
The pathogenic spirochetes Borrelia burgdorferi, B. hermsii, B. recurrentis, Treponema
denticola and Leptospira spp. are the etiologic agents of Lyme disease, relapsing fever …

Recombinant multiepitope protein for diagnosis of leptospirosis

X Lin, Y Chen, J Yan - Clinical and Vaccine Immunology, 2008 - Am Soc Microbiol
Leptospirosis is an emerging infectious disease and is considered to be the most
widespread zoonotic disease in the world. It can be misdiagnosed because manifestations …

Plasminogen Binding Proteins and Plasmin Generation on the Surface of Leptospira spp.: The Contribution to the Bacteria‐Host Interactions

ML Vieira, MV Atzingen, R Oliveira… - BioMed Research …, 2012 - Wiley Online Library
Leptospirosis is considered a neglected infectious disease of human and veterinary
concern. Although extensive investigations on host‐pathogen interactions have been …