The production, differentiation, and presence of male gametes represent inimitable
challenges to the immune system, as they are unique to the body and appear long after the …

Male fertility results from a complex interplay of physiological, environmental, and genetic
factors. It is conditioned by the properly developed anatomy of the reproductive system …

The testes produce the male gametes and the male sexual hormones (androgens). The term
spermatogenesis describes and includes all the processes involved in the production of …

Mast-cell products can stimulate fibroblast proliferation, implying that these cells are key
players in fibrosis. One mast-cell product, the serine protease tryptase, is known to activate …

Objective: To determine whether human testicular mast cells contain the potent fibroblast
growth factor tryptase and to examine changes in mast cell morphology and intratesticular …

Macrophages are important in the activation of innate immune responses and in a tissue-
specific manner in the maintenance of organ homeostasis. Testicular macrophages (TM) …

Testicular dysfunction correlates with increased testicular mast cells. Mast cells can activate
fibroblasts and promote collagen synthesis. The aim of the study was to examine testicular …

BACKGROUND The molecular basis of human testicular dysfunction is largely unknown.
Global gene expression profiling of testicular biopsies might reveal an expression signature …

A number of studies have indicated that testicular macrophages play an important role in
regulating steroidogenesis of Leydig cells and maintain homeostasis within the testis. The …

Biogenic amines are signaling molecules with multiple roles in the central nervous system
and in peripheral organs, including the gonads. A series of studies indicated that these …