Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural
degenerative disease usually caused by gene defects that disrupt the function or …

Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …

Electrical synaptic transmission via gap junctions underlies direct and rapid neuronal
communication in the central nervous system. The diversity of functional roles played by …

Aging is associated with increased risk for type 2 diabetes, resulting from reduced insulin
sensitivity and secretion. Reduced insulin secretion can result from reduced proliferative …

Beta cells couple stimulation by glucose with insulin secretion and impairments in this
coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) …

Gap junctions are ubiquitous throughout the nervous system, mediating critical signal
transmission and integration, as well as emergent network properties. In mammalian retina …

Gap junctions are recognized in the electron microscope as dense starchy areas of opposed
membrane between two cells. Small tracer molecules such as Neurobiotin pass through the …

Myopia is a substantial public health problem worldwide. In the myopic retina, distant
images are focused in front of the photoreceptors. The cells and mechanisms for retinal …

Key points The pancreatic islets of Langerhans maintain glucose homeostasis through
insulin secretion, where insulin secretion dynamics are regulated by intracellular Ca2+ …

Neurons build vast gap junction-coupled networks (GJ-nets) that are permeable to ions or
small molecules, enabling lateral signaling. Herein, we investigate (1) the effect of blinding …