Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases
NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
Brain metabolism in health, aging, and neurodegeneration
S Camandola, MP Mattson - The EMBO journal, 2017 - embopress.org
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …
activity in neuronal circuits, and from environmental energetic stressors such as food …
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse
H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …
Landmark-based deep multi-instance learning for brain disease diagnosis
Abstract In conventional Magnetic Resonance (MR) image based methods, two stages are
often involved to capture brain structural information for disease diagnosis, ie, 1) manually …
often involved to capture brain structural information for disease diagnosis, ie, 1) manually …
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …
Joint classification and regression via deep multi-task multi-channel learning for Alzheimer's disease diagnosis
In the field of computer-aided Alzheimer's disease (AD) diagnosis, jointly identifying brain
diseases and predicting clinical scores using magnetic resonance imaging (MRI) have …
diseases and predicting clinical scores using magnetic resonance imaging (MRI) have …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Increasing brain gamma activity improves episodic memory and restores cholinergic dysfunction in Alzheimer's disease
Objective This study aimed to assess whether non‐invasive brain stimulation with
transcranial alternating current stimulation at gamma‐frequency (γ‐tACS) applied over the …
transcranial alternating current stimulation at gamma‐frequency (γ‐tACS) applied over the …