Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates
A Gangjee, Y Zeng, T Talreja, JJ McGuire… - Journal of medicinal …, 2007 - ACS Publications
The classical antifolate N-{4-[(2, 4-diamino-5-ethyl-7 H-pyrrolo [2, 3-d] pyrimidin-6-yl)
sulfanyl] benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3− 17) were …
sulfanyl] benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3− 17) were …
Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I
A Gangjee, HD Jain, S Kurup - Anti-Cancer Agents in Medicinal …, 2007 - ingentaconnect.com
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …
Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II
A Gangjee, HD Jain, S Kurup - Anti-Cancer Agents in Medicinal …, 2008 - ingentaconnect.com
Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …
Novel 1, 3, 4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents
QR Du, DD Li, YZ Pi, JR Li, J Sun, F Fang… - Bioorganic & medicinal …, 2013 - Elsevier
A series of novel 1, 3, 4-oxadiazole thioether derivatives (compounds 9–44) were designed
and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer …
and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer …
Baiting Proteins with C60
M Calvaresi, F Zerbetto - ACS nano, 2010 - ACS Publications
About 20 proteins are known to modify their activity upon interaction with C60. Their
structures are present in a database that includes more than 1200 protein structures …
structures are present in a database that includes more than 1200 protein structures …
Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase Inhibitors and Antitumor Agents: Synthesis and Biological Activities of 2,4-Diamino-5-methyl-6 …
A Gangjee, O Adair, SF Queener - Journal of medicinal chemistry, 1999 - ACS Publications
Thirteen 2, 4-diamino-5-methyl-6-[(monosubstituted anilino) methyl] pyrido [2, 3-d]
pyrimidines 5− 17 were synthesized as potential Pneumocystis carinii (pc) and Toxoplasma …
pyrimidines 5− 17 were synthesized as potential Pneumocystis carinii (pc) and Toxoplasma …
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent
A Gangjee, J Yu, JJ McGuire, V Cody… - Journal of medicinal …, 2000 - ACS Publications
A novel N-{2-amino-4-methyl [(pyrrolo [2, 3-d] pyrimidin-5-yl) ethyl] benzoyl}-l-glutamic acid
(3a) was designed and synthesized as a potent dual inhibitor of thymidylate synthase (TS) …
(3a) was designed and synthesized as a potent dual inhibitor of thymidylate synthase (TS) …
Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines
Classical and nonclassical isosteric C8− N9 bridged analogues of the multitargeted
antifolate LY231514 were synthesized as inhibitors of thymidylate synthase (TS) …
antifolate LY231514 were synthesized as inhibitors of thymidylate synthase (TS) …
Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate …
A Gangjee, W Li, RL Kisliuk, V Cody… - Journal of medicinal …, 2009 - ACS Publications
N-{4-[(2-Amino-6-ethyl-4-oxo-3, 4-dihydrothieno [2, 3-d] pyrimidin-5-yl) thio] benzoyl}-l-
glutamic acid 2 and 13 nonclassical analogues 2a− 2m were synthesized as potential dual …
glutamic acid 2 and 13 nonclassical analogues 2a− 2m were synthesized as potential dual …
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical …
A Gangjee, HD Jain, J Phan, X Lin… - Journal of medicinal …, 2006 - ACS Publications
We designed and synthesized a classical analogue N-[4-[(2-amino-6-ethyl-3, 4-dihydro-4-
oxo-7 H-pyrrolo [2, 3-d] pyrimidin-5-yl) thio] benzoyl]-l-glutamic acid (4) and thirteen …
oxo-7 H-pyrrolo [2, 3-d] pyrimidin-5-yl) thio] benzoyl]-l-glutamic acid (4) and thirteen …