The systematic review of the marine pharmacology literature from 2014 to 2015 was
completed in a manner consistent with the 1998–2013 reviews of this series. Research in …

Oceans cover more than 70 percent of the surface of our planet and are characterized by
huge taxonomic and chemical diversity of marine organisms. Several studies have shown …

Small-molecule compounds that elicit mRNA-selective translation repression have attracted
interest due to their potential for expansion of druggable space. However, only a limited …

Sindbis virus (SINV) contains an RNA genome of positive polarity with two open reading
frames (ORFs). The first ORF is translated from the genomic RNA (gRNA), rendering the viral …

The marine natural product pateamine A (1) and its somewhat simplified designer analogue
DMDA-Pat A (2)(DMDA= desmethyl-desamino) are potently cytotoxic compounds; most …

Pateamines, derived from the sponge Mycale hentscheli, function as inhibitors of the RNA
helicase eIF4A and exhibit promising antiviral and anticancer properties. eIF4A plays a …

Worldwide urbanization and subsequent migration have accelerated the emergence and
spread of diverse novel human diseases. Among them, diseases caused by viruses could …

Translation of Sindbis virus subgenomic mRNA (sgmRNA) can occur after inactivation of
eIF2 by phosphorylation in mammalian cells. Several studies have suggested that eIF2 can …

The marine macrolide pateamine A and its non‐natural sibling DMDA‐Pat A are potent
translation inhibitors targeting the eukaryotic initiation factor 4A (eIF4A), an enzyme with …

Animal viruses have evolved a variety of strategies to ensure the efficient translation of their
mRNAs. One such strategy is the use of internal ribosome entry site (IRES) elements, which …