In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

Rodents are widely used to mimic human diseases to improve understanding of the causes
and progression of disease symptoms and to test potential therapeutic interventions …

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Mutations in the gene encoding leptin (LEP) typically lead to an absence of circulating leptin
and to extreme obesity. We describe a 2-year-old boy with early-onset extreme obesity due …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …

This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …