Kidney metabolism and acid–base control: back to the basics
PH Imenez Silva, N Mohebbi - Pflügers Archiv-European Journal of …, 2022 - Springer
Kidneys are central in the regulation of multiple physiological functions, such as removal of
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …
Pathogenic relationships in cystic fibrosis and renal diseases: CFTR, SLC26A9 and anoctamins
K Kunzelmann, J Ousingsawat, A Kraus… - International journal of …, 2023 - mdpi.com
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …
have more in common than initially suspected, as they all participate in the pathogenic …
Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and α-MSH Realms
O Al Musaimi - Biomolecules, 2024 - mdpi.com
Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of
insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 …
insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 …
Challenged urine bicarbonate excretion as a measure of cystic fibrosis transmembrane conductance regulator function in cystic fibrosis
P Berg, MV Sorensen, AQ Rousing… - Annals of Internal …, 2022 - acpjournals.org
Background: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly,
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …
Cadmium transport by mammalian ATP-binding cassette transporters
F Thévenod, WK Lee - Biometals, 2024 - Springer
Cellular responses to toxic metals depend on metal accessibility to intracellular targets,
reaching interaction sites, and the intracellular metal concentration, which is mainly …
reaching interaction sites, and the intracellular metal concentration, which is mainly …
Novel functions of the anion exchanger AE4 (SLC4A9)
H Vitzthum, C Meyer-Schwesinger, H Ehmke - Pflügers Archiv-European …, 2024 - Springer
The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …
SLC26A9 in airways and intestine: secretion or absorption?
K Kunzelmann, R Centeio, J Ousingsawat, K Talbi… - Channels, 2023 - Taylor & Francis
ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …
Alkalosis-induced hypoventilation in cystic fibrosis: the importance of efficient renal adaptation
P Berg, JF Andersen, MV Sørensen… - Proceedings of the …, 2022 - National Acad Sciences
The lungs and kidneys are pivotal organs in the regulation of body acid–base homeostasis.
In cystic fibrosis (CF), the impaired renal ability to excrete an excess amount of HCO3− into …
In cystic fibrosis (CF), the impaired renal ability to excrete an excess amount of HCO3− into …
Mechanisms and physiological relevance of acid-base exchange in functional units of the kidney
This review discusses the importance of homeostasis with a particular emphasis on the acid-
base (AB) balance, a crucial aspect of pH regulation in living systems. Two primary organ …
base (AB) balance, a crucial aspect of pH regulation in living systems. Two primary organ …
Loss of the secretin receptor impairs renal bicarbonate excretion and aggravates metabolic alkalosis in mice during acute base-loading
Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …