HELLP syndrome—holistic insight into pathophysiology

A Petca, BC Miron, I Pacu, MC Dumitrașcu… - Medicina, 2022 - mdpi.com
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and
low platelets, represents a severe pregnancy complication typically associated with …

Evolving mechanistic insights into galectin functions

CM Arthur, MD Baruffi, RD Cummings… - Galectins: Methods and …, 2015 - Springer
Galectins are an evolutionarily ancient family of glycan-binding proteins (GBPs) and are
found in all animals. Although they were discovered over 30 years ago, ideas about their …

Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression

D Tang, J Gao, S Wang, N Ye, Y Chong, Y Huang… - Tumor Biology, 2016 - Springer
Background Galectin-1, an evolutionarily conserved glycan-binding protein with angiogenic
potential, was recently identified as being overexpressed in cancer-associated fibroblasts …

Galectins: an ancient family of carbohydrate binding proteins with modern functions

H Verkerke, M Dias-Baruffi, RD Cummings… - Galectins: Methods and …, 2022 - Springer
Galectins are a large family of carbohydrate binding proteins with members in nearly every
lineage of multicellular life. Through tandem and en-mass genome duplications, over 15 …

Human placental transcriptome reveals critical alterations in inflammation and energy metabolism with fetal sex differences in spontaneous preterm birth

YC Lien, Z Zhang, Y Cheng, E Polyak, L Sillers… - International Journal of …, 2021 - mdpi.com
A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas,
and waste exchanges between the maternal and fetal circulations and is an important …

Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency

N Freitag, I Tirado-Gonzalez, G Barrientos… - Cell Death & …, 2020 - nature.com
Fetal growth restriction (FGR) is the most common pregnancy complication in developed
countries. Pregnancies affected by FGR, frequently concur with complications and high risk …

Placental galectins are key players in regulating the maternal adaptive immune response

A Balogh, E Toth, R Romero, K Parej, D Csala… - Frontiers in …, 2019 - frontiersin.org
Galectins are potent immunomodulators that regulate maternal immune responses in
pregnancy and prevent the rejection of the semi-allogeneic fetus that also occurs in …

Involvement of galectin-1 in reproduction: past, present and future

G Barrientos, N Freitag… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND After recognition of its pivotal contribution to fetomaternal tolerance, the
study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in …

The functional roles of protein glycosylation in human maternal–fetal crosstalk

J Zhong, J Li, GJ Burton, H Koistinen… - Human …, 2024 - academic.oup.com
BACKGROUND The establishment of maternal–fetal crosstalk is vital to a successful
pregnancy. Glycosylation is a post-translational modification in which glycans …

Pregnancy galectinology: insights into a complex network of glycan binding proteins

SM Blois, G Dveksler, GR Vasta, N Freitag… - Frontiers in …, 2019 - frontiersin.org
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins,
consisting of 15 different types, each with a specific function. Galectins contribute to …