GNAO1 disorder is a rare autosomal dominant neurodevelopmental syndrome that is
clinically manifested by developmental delay,(early onset) epilepsy, and movement …

Cerebral palsy (CP) has historically been attributed to acquired insults, but emerging
research suggests that genetic variations are also important causes of CP. While microarray …

De novo mutations in GNAO1, the gene encoding the major neuronal G protein Gαo, cause
a spectrum of pediatric encephalopathies with seizures, motor dysfunction, and …

Background The GNAO1 gene encodes the α-subunit (Gαo) of the heterotrimeric guanine
nucleotide-binding protein (G protein). The aim of this study was to explore the clinical …

Background Patients carrying pathogenic variants in GNAO1 present a phenotypic spectrum
ranging from severe early‐onset epileptic encephalopathy and developmental delay to mild …

Background Defects in GNAO1, the gene encoding the major neuronal G‐protein Gαo, are
related to neurodevelopmental disorders, epilepsy, and movement disorders. Nevertheless …

Cerebral palsy (CP) is the core neurodevelopmental disorder affecting movement. Several
distinct movement disorders can occur in people with cerebral palsy. Dystonia is a …

GNAO1-related disorder encompasses a broad phenotypic continuum that includes
hyperkinetic movement disorders and/or epilepsy and is typically associated with …

Background GNAO1-related disorders (GNAO1-RD) encompass a diverse spectrum of
neurodevelopmental and movement disorders arising from variants in the GNAO1 gene …

Mutations in the GNAO1 gene, which encodes the abundant brain G-protein Gα o, result in
neurologic disorders characterized by developmental delay, epilepsy, and movement …