Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications

YV Suseela, N Narayanaswamy, S Pratihar… - Chemical Society …, 2018 - pubs.rsc.org
The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …

Benzothiazole based fluorescent probes for the detection of biomolecules, physiological conditions, and ions responsible for diseases

S Das, HK Indurthi, P Asati, P Saha, DK Sharma - Dyes and Pigments, 2022 - Elsevier
Benzothiazole-based fluorescent probes are formed by decorating benzothiazole
fluorophore with a small chemical fragment capable of detecting a particular biological …

Recent advances in design of fluorescence-based assays for high-throughput screening

X Fang, Y Zheng, Y Duan, Y Liu, W Zhong - Analytical chemistry, 2018 - ACS Publications
Significant improvements in disease management have been achieved in the past few
decades. Using cancer as an example, survival rates have increased dramatically in …

Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast …

W Long, BX Zheng, Y Li, XH Huang, DM Lin… - Nucleic acids …, 2022 - academic.oup.com
DNA G4-structures from human c-MYC promoter and telomere are considered as important
drug targets; however, the developing of small-molecule-based fluorescent binding ligands …

Design of Modular G‐quadruplex Ligands

AR Duarte, E Cadoni, AS Ressurreição… - …, 2018 - Wiley Online Library
Guanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …

Cellular Visualization of G-Quadruplex RNA via Fluorescence-Lifetime Imaging Microscopy

J Robinson, SG Stenspil, K Maleckaite… - Journal of the …, 2023 - ACS Publications
Over the past decade, appreciation of the roles of G-quadruplex (G4) structures in cellular
regulation and maintenance has rapidly grown, making the establishment of robust methods …

Broad applications of thiazole orange in fluorescent sensing of biomolecules and ions

O Suss, L Motiei, D Margulies - Molecules, 2021 - mdpi.com
Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and
better understanding various biological systems. Therefore, it has become increasingly …

An Aggregating Amphiphilic Squaraine: A Light‐up Probe That Discriminates Parallel G‐Quadruplexes

V Grande, F Doria, M Freccero… - Angewandte Chemie, 2017 - Wiley Online Library
Abstract G‐quadruplexes (G4s) are peculiar DNA or RNA tertiary structures that are involved
in the regulation of many biological events within mammalian cells, bacteria, and viruses …

Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

BX Zheng, J Yu, W Long, KH Chan… - Chemical …, 2023 - pubs.rsc.org
The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

Small molecule fluorescent probes for G-quadruplex visualization as potential cancer theranostic agents

P Chilka, N Desai, B Datta - Molecules, 2019 - mdpi.com
G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …