We discuss the evolution of OrbitrapTM mass spectrometry (MS) from its birth in the late
1990s to its current role as one of the most prominent techniques for MS. The Orbitrap mass …

Mass spectrometry is a central analytical technique for protein research and for the study of
biomolecules in general. Driven by the need to identify, characterize, and quantify proteins …

The growing trend toward high-throughput proteomics demands rapid liquid
chromatography–mass spectrometry (LC–MS) cycles that limit the available time to gather …

Mass spectrometry-based proteomics has greatly benefitted from enormous advances in
high resolution instrumentation in recent years. In particular, the combination of a linear ion …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Research areas such as proteomics and metabolomics are driving the demand for mass
spectrometers that have high performance but modest power requirements, size, and cost …

Mass accuracy is a key parameter of mass spectrometric performance. TOF instruments can
reach low parts per million, and FT-ICR instruments are capable of even greater accuracy …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

Design and performance of a novel hybrid mass spectrometer is described. It couples a
linear ion trap mass spectrometer to an orbitrap mass analyzer via an rf-only trapping …

Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely
deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the …