Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …

Transforming growth factor β (TGFβ) pathways are implicated in metazoan development,
adult homeostasis and disease. TGFβ ligands signal via receptor serine/threonine kinases …

Somatic cells can be reprogrammed to an ES‐like state to create induced pluripotent stem
cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc …

Reduced insulin/IGF signaling increases lifespan in many animals. To understand how
insulin/IGF mediates lifespan in Drosophila, we performed chromatin immunoprecipitation …

In many cases, the level, positioning and timing of signaling through the bone
morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in …

TGFβ is secreted in a latent state and must be “activated” by molecules that facilitate its
release from a latent complex and allow binding to high affinity cell surface receptors …

Advances in our understanding of the many levels of regulation of TGFβand BMP signaling
were reported at the recent FASEB Summer Conference entitledThe TGFβ Superfamily …

Mammalian cells can decode the concentration of extracellular transforming growth factor‐β
(TGF‐β) and transduce this cue into appropriate cell fate decisions. How variable TGF‐β …

Crocus sativus L.(Saffron) is an economically vital medicinal and aromatic plant. Saffron is
known as the “Golden Condiment” being the world's highest priced spice (€ 30,000/kg) …

Planarians are flatworms and can perform whole-body regeneration. This ability involves a
mechanism to distinguish between anterior-facing wounds that require head regeneration …