The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …

The ability of microglia to acquire diverse states of activation, or phenotypes, reflects
different features that are determinant for their contribution to homeostasis in the adult CNS …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …

In this review, I will consider the dual nature of Cannabis and cannabinoids. The duality
arises from the potential and actuality of cannabinoids in the laboratory and clinic and the …

Cannabis has been shown to be beneficial in the treatment of pain and inflammatory
diseases. The biological effect of cannabis is mainly attributed to two major cannabinoids …

Background Cannabidiol (CBD) is one of the main phytocannabinoids found in Cannabis
sativa. In contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors …

Multiple sclerosis (MS) is a chronic and disabling disorder of the central nervous system
(CNS) characterized by neuroinflammation leading to demyelination. Recently a …

Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol
(THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with …

abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …