The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Covering: up to July 2011 Sesquiterpene synthases catalyse the metal dependent turnover
of farnesyl diphosphate to generate a class of natural products characterised by an …

This review summarises known sesquiterpenes whose biosyntheses proceed through the
intermediate germacrene A. First, the occurrence and biosynthesis of germacrene A in …

Aristolochene synthase, a metal-dependent sesquiterpene cyclase from Aspergillus terreus,
catalyzes the ionization-dependent cyclization of farnesyl diphosphate (FPP) to form the …

Stabilization of the reaction intermediate eudesmane cation (3) through interaction with Trp
334 during catalysis by aristolochene synthase from Penicillium roqueforti was investigated …

Recombinant (+)-δ-cadinene synthase (DCS) from Gossypium arboreum catalyzes the metal-
dependent cyclization of (E, E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene δ …

Terpene synthases catalyse the first step in the conversion of prenyl diphosphates to
terpenoids. They act as templates for their substrates to generate a reactive conformation …

Terpenes are the largest group of natural products with important and diverse biological
roles, while of tremendous economic value as fragrances, flavours and pharmaceutical …

A small library of novel germacrenes was generated using a combination of two plant
enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate …

The enantioselective synthesis of α, α-disubstituted cycloalkanones has been developed
using a primary amine, thiourea-based dual catalysis pathway. A range of electrophiles and …