Pathophysiology of hepatitis C virus infection and related liver disease

JM Pawlotsky - Trends in microbiology, 2004 - cell.com
Hepatitis C virus (HCV) infects over 170 million people worldwide. Chronic infection occurs
in 50–80% of cases and eventually leads to cirrhosis and hepatocellular carcinoma. The …

Recent advances in the molecular biology of hepatitis C virus

S Rosenberg - Journal of molecular biology, 2001 - Elsevier
The Hepatitis C virus is a positive-stranded RNA virus which is the causal agent for a chronic
liver infection afflicting more than 170,000,000 people world-wide. The HCV genome is …

Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically …

N Appel, T Pietschmann, R Bartenschlager - Journal of virology, 2005 - Am Soc Microbiol
Nonstructural protein 5A of the hepatitis C virus (HCV) is a highly phosphorylated molecule
implicated in multiple interactions with the host cell and most likely involved in RNA …

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

I Hamamoto, Y Nishimura, T Okamoto, H Aizaki… - Journal of …, 2005 - Am Soc Microbiol
The hepatitis C virus (HCV) nonstructural protein (NS) 5A is a phosphoprotein that
associates with various cellular proteins and participates in the replication of the HCV …

Protein-protein interactions between hepatitis C virus nonstructural proteins

M Dimitrova, I Imbert, MP Kieny, C Schuster - Journal of virology, 2003 - Am Soc Microbiol
Replication of the hepatitis C virus (HCV) genome has been proposed to take place close to
the membrane of the endoplasmic reticulum in membrane-associated replicase complexes …

[HTML][HTML] HCV genome and life cycle

S Chevaliez, JM Pawlotsky - Hepatitis C viruses: genomes and …, 2006 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) infection afflicts more than 170 million people worldwide, with the
great majority of patients with acute hepatitis C developing chronic HCV infection. It can …

Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on …

M Pascu, P Martus, M Höhne, B Wiedenmann, U Hopf… - Gut, 2004 - gut.bmj.com
Background and aims: There is growing evidence that the response of hepatitis C virus
(HCV) genotype 1b infected patients towards interferon (IFN) therapy is influenced by the …

Amino Acid and Peptide‐Based Antiviral Agents

AS Skwarecki, MG Nowak, MJ Milewska - ChemMedChem, 2021 - Wiley Online Library
A significant number of antiviral agents used in clinical practice are amino acids, short
peptides, or peptidomimetics. Among them, several HIV protease inhibitors (eg lopinavir …

[PDF][PDF] Hepatitis C virus resistance to antiviral therapy

JM Pawlotsky - Hepatology, 2000 - Wiley Online Library
Research produces highly efficient antiviral drugs. At the same time, viruses develop
sophisticated strategies to evade their actions. Resistance to antiviral therapy has become a …

Hepatitis C virus NS5A as a potential viral Bcl‐2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma

YL Chung, ML Sheu, SH Yen - International journal of cancer, 2003 - Wiley Online Library
Abstract Treatment of hepatocellular carcinoma (HCC) cells with butyrate can induce
apoptosis irrespective of hepatitis B virus integration. No information is available, however …