Mechanisms contributing to adverse outcomes of COVID-19 in obesity

M Sudhakar, SB Winfred, G Meiyazhagan… - Molecular and cellular …, 2022 - Springer
A growing amount of epidemiological data from multiple countries indicate an increased
prevalence of obesity, more importantly central obesity, among hospitalized subjects with …

Potential mechanisms underlying COVID-19-mediated central and peripheral demyelination: Roles of the RAAS and ADAM-17

KB Oliveira, FMA de Souza, LBM de Sá… - Molecular …, 2025 - Springer
Demyelination is among the most conspicuous neurological sequelae of SARS-CoV-2
infection (COVID-19) in both the central (CNS) and peripheral (PNS) nervous systems …

[PDF][PDF] Bioactive compounds screening of Rafflessia sp. and Sapria sp.(Family: Rafflesiaceae) as anti-SARS-CoV-2 via tetra inhibitors: An in silico research

NS Aini, VD Kharisma, A Ansori, AAA Murtadlo… - Journal of Pharmacy …, 2023 - jppres.com
Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly
spread, causing a global pandemic with diverse symptoms and increased risk of mortality …

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

K Tanimoto, K Hirota, T Fukazawa, Y Matsuo… - Scientific Reports, 2021 - nature.com
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely
important for developing effective therapies against COVID-19, we focused on the …

Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges

IS Mahmoud, YB Jarrar - Molecular Biology Reports, 2021 - Springer
The transmembrane protease serine 2 (TMPRSS2) is a membrane anchored protease that
primarily expressed by epithelial cells of respiratory and gastrointestinal systems and has …

Repressed Ang 1–7 in COVID-19 Is inversely associated with inflammation and coagulation

RM Carpenter, MK Young, WAO Petri, GR Lyons… - Msphere, 2022 - Am Soc Microbiol
The coronavirus SARS-CoV-2 infects host cells by binding to the angiotensin-converting
enzyme 2 (ACE2) receptor, which belongs to an anti-inflammatory, anti-thrombotic counter …

Ectodomain shedding of proteins important for SARS-CoV-2 pathogenesis in plasma of tobacco cigarette smokers compared to electronic cigarette vapers: a cross …

T Kelesidis, M Sharma, S Satta, E Tran, R Gupta… - Journal of Molecular …, 2023 - Springer
The impact of tobacco cigarette (TCIG) smoking and electronic cigarette (ECIG) vaping on
the risk of development of severe COVID-19 is controversial. The present study investigated …

[HTML][HTML] Multifactorial Traits of SARS-CoV-2 Cell Entry Related to Diverse Host Proteases and Proteins

J You, JH Seok, M Joo, JY Bae, JI Kim… - Biomolecules & …, 2021 - ncbi.nlm.nih.gov
The most effective way to control newly emerging infectious disease, such as the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, is to strengthen …

[HTML][HTML] Rafflesia sp. and Sapria sp. against SARS-CoV-2

Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly
spread, causing a global pandemic with diverse symptoms and increased risk of mortality …