Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …

Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …

Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder that affects 7 out of
1,000,000 live births and has been associated with mutations in components of the …

Middle East and North Africa region (MENA) populations are of different ethnic origins.
Consanguineous marriages are common practice with an overall incidence ranging …

Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline
predisposition to hematologic malignancies, referred to as germline predisposition herein …

Objective: To present the genetic causes of patients with primary immune deficiencies (PIDs)
in Kuwait between 2004 and 2017. Methods: The data was obtained from the Kuwait …

Prolonged cytopenias are a non-specific sign with a wide differential diagnosis. Among
inherited disorders, cytopenias predisposing to leukemia require a timely and accurate …

MYSM1 has emerged as an important regulator of hematopoietic stem cell function, blood
cell production, immune response, and other aspects of mammalian physiology. It is a …

The differential diagnosis of marrow failure (MF) is crucial in the diagnostic work‐up, since
genetic forms require specific care. We retrospectively studied all patients with single/multi …

Background Histone epigenetic modification disorder is an important predisposing factor for
the occurrence and development of many cancers, including colorectal cancer (CRC). The …