▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

Scientific revolution [1] implies a transformation of the world view in which a dominant
paradigm is substituted by a new one, one which furnishes an ameliorated comprehension …

The folate antagonist methotrexate (MTX) is extensively used in graft-versus-host disease,
rheumatoid arthritis, and other chronic inflammatory disorders. In addition to its …

Activation-induced cell death (AICD) of lymphocytes is an important mechamism of self-
tolerance. In CD4+ T cells, AICD is mediated by the Fas pathway and is enhanced by IL-2 …

Programmed cell death, or apoptosis, is important in homeostasis of the immune system: for
example, non-functional or auto-reactive lymphocytes are eliminated through apoptosis …

The nonpolymorphic soluble HLA-G1 (sHLA-G1) isoform has been reported to be secreted
by trophoblast cells at the materno-fetal interface, suggesting that it may act as …

To assess the involvement of the immune system in Parkinson's disease we studied the
phenotype of circulating lymphocytes in 30 untreated and 34 treated patients. We found a …

Background. The mechanisms of action of polyclonal antithymocyte globulins (ATGs) are still
poorly understood and the selection of doses used in different clinical applications …

Polyclonal horse antilymphocyte and rabbit antithymocyte globulins (ATGs) are currently
used in severe aplastic anemia and for the treatment of organ allograft acute rejection and …

Limonoids have been shown to inhibit the growth of estrogen receptor-negative and-positive
human breast cancer cells in culture. The primary objective of this study was to test the …