Reconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drug

T Singh, S Thapliyal, S Bhatia, V Singh, M Singh… - Life Sciences, 2022 - Elsevier
Minocycline, a second-generation tetracycline antibiotic is being widely tested in animals as
well as clinical settings for the management of multiple neurological disorders. The drug has …

Status epilepticus triggers time-dependent alterations in microglia abundance and morphological phenotypes in the hippocampus

SK Wyatt-Johnson, SA Herr, AL Brewster - Frontiers in neurology, 2017 - frontiersin.org
Status epilepticus (SE) is defined by the occurrence of prolonged “non-stop” seizures that
last for at least 5 min. SE provokes inflammatory responses including the activation of …

Minocycline, but not doxycycline attenuates NMDA-induced [Ca2+] i and excitotoxicity

Y Lu, Y Yang, W Chen, N Du, Y Du, H Gu, Q Liu - NeuroReport, 2021 - journals.lww.com
Minocycline and doxycycline, two semisynthetic second-generation tetracyclines, are
reported to provide neuroprotection against brain injury and glutamate-induced neurotoxicity …

Doxycycline protects against pilocarpine-induced convulsions in rats, through its antioxidant effect and modulation of brain amino acids

CRA Nogueira, FM Damasceno… - Pharmacology …, 2011 - Elsevier
This work evaluated doxycycline (2nd generation tetracycline) protection against pilocarpine-
induced convulsions in rats. The animals were treated with doxycycline (Dox: 10 to100 …

Regional differences in the neuroprotective effect of minocycline in a mouse model of global forebrain ischemia

KO Cho, SK Kim, YJ Cho, KW Sung, SY Kim - Life sciences, 2007 - Elsevier
We investigated the effect of minocycline on neuronal damage in the hippocampus and
striatum in a mouse model of transient global forebrain ischemia. Male C57BL/6 mice were …

[HTML][HTML] Impaired learning and memory in male mice induced by sodium arsenite was associated with MMP-2/MMP-9-mediated blood-brain barrier disruption and …

L Cheng, Y Zhang, M Lv, W Huang, K Zhang… - Ecotoxicology and …, 2024 - Elsevier
Arsenic is a widespread environmental contaminant known to accumulate in the brain,
leading to cognitive impairment. However, the exact mechanisms by which arsenic causes …

Assessment of the orbit morphometry on West Anatolian dry skulls

GN Yonguc, N Gocmen-Mas, F Aksu… - Folia …, 2018 - journals.viamedica.pl
The orbit is very frequently damaged by traumas which result in not only bone deficits, but
also functional deformities if reconstruction is not appropriate. Anatomical exposure of the …

Effect of nifedipine on Hippocampal neuron number in Penicillin-Induced Epileptic Rats

I Yilmaz, I Akdoğan, E Kaya, GN Yonguc - Turkish Neurosurgery, 2014 - gcris.pau.edu.tr
Aim: Epileptic seizures lead to neuronal loss in the hippocampus. Experimental epilepsy can
be induced by direct application of various chemicals to cerebral cortex. Nifedipine is an L …

Presentation of the change in the number of hippocampal neurons by stereological method in surviving cases of mechanical asphyxia: an experimental rat study

CD Cenger, A Kurtuluş, K Acar, B Boz - Romanian Journal of Legal …, 2012 - gcris.pau.edu.tr
Asphyxia is the most common death cause in Forensic Medicine. Strangulations do not
always result in death. Cases recovering from asphyxia have many disturbances in different …

Neonatal term sıçanlarda oluşturulan hipoksik iskemik beyin hasarı modelinde intraperitoneal uygulanan valproik asit ve folik asidin beyin hasarına etkileri

M Demirayak - 2008 - gcris.pau.edu.tr
Hipoksik-iskemik ensefalopati (HİE) yenidoğanlarda akut mortalite ve morbiditenin önemli
bir nedenidir. Valproik asit (VA) geniş spektrumlu bir antikonvülzandır. Folik asit (FA) ise tek …