TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
Mechanisms of TGFβ-induced epithelial–mesenchymal transition
A Moustakas, CH Heldin - Journal of clinical medicine, 2016 - mdpi.com
Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …
embryonic cells to generate migratory descendants that populate new sites and establish …
The biochemical basis of microRNA targeting efficacy
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
starBase v2. 0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
Although microRNAs (miRNAs), other non-coding RNAs (ncRNAs)(eg lncRNAs,
pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been …
pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been …
BMP signalling: agony and antagony in the family
Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated
proteins that regulate a wide range of developmental processes, including limb and kidney …
proteins that regulate a wide range of developmental processes, including limb and kidney …
Unambiguous identification of miRNA: target site interactions by different types of ligation reactions
S Grosswendt, A Filipchyk, M Manzano, F Klironomos… - Molecular cell, 2014 - cell.com
To exert regulatory function, miRNAs guide Argonaute (AGO) proteins to partially
complementary sites on target RNAs. Crosslinking and immunoprecipitation (CLIP) assays …
complementary sites on target RNAs. Crosslinking and immunoprecipitation (CLIP) assays …
MicroRNAs: crucial regulators of placental development
MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide
range of cellular processes mainly through the regulation of translation and mRNA stability …
range of cellular processes mainly through the regulation of translation and mRNA stability …
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells
AK Jain, K Allton, M Iacovino, E Mahen… - PLoS …, 2012 - journals.plos.org
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this
is strictly due to repression of proliferation remains a subject of debate. Here, we show that …
is strictly due to repression of proliferation remains a subject of debate. Here, we show that …
[HTML][HTML] Post-translational regulation of TGF-β receptor and Smad signaling
P Xu, J Liu, R Derynck - FEBS letters, 2012 - Elsevier
TGF-β family signaling through Smads is conceptually a simple and linear signaling
pathway, driven by sequential phosphorylation, with type II receptors activating type I …
pathway, driven by sequential phosphorylation, with type II receptors activating type I …