The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …

CRM1 is distantly related to receptors that mediate nuclear protein import and was
previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in …

Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms
governing this transport process are not well understood. Using a novel protein export assay …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Histone deacetylases (HDACs) are a diverse family of essential transcriptional regulatory
enzymes, that function through the spatial and temporal recruitment of protein complexes. As …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

Cytosolic proteins bearing a classical nuclear localization signal enter the nucleus bound to
a heterodimer of importin-α and importin-β (also called karyopherin-α and-β). The formation …