Research into the potential benefits of artificial intelligence for comprehending the intricate
biology of cancer has grown as a result of the widespread use of deep learning and …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

The immune-cell origin of hematologic malignancies provides a unique avenue for the
understanding of both the mechanisms of immune responsiveness and immune escape …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular biology at an unprecedented resolution, enabling the characterization of cellular …

Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in
treating both hematologic malignancies and solid tumors. Although instances of rapid tumor …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

Despite a high response rate in chimeric antigen receptor (CAR) T cell therapy for acute
lymphocytic leukaemia (ALL),–, approximately 50% of patients relapse within the first year …

Over the past decade, immunotherapy has emerged as one of the most promising
approaches to cancer treatment. The use of immune checkpoint inhibitors has resulted in …

Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state
of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion …