The neuronal ceroid lipofuscinoses (NCL) are severe neurodegenerative lysosomal storage
disorders of childhood, characterized by accumulation of autofluorescent ceroid …

The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative
lysosomal storage disorders (LSDs), traditionally grouped together based on shared clinical …

Background Pulmonary metastasis continues to be the most common cause of death in
osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has …

Microglia are the main immune cells of the brain, and under some circumstances they can
play an important role in removal of fibrillar Alzheimer amyloid β peptide (fAβ). Primary …

The most common form of the childhood neurodegenerative disease late infantile neuronal
ceroid lipofuscinosis (also called Batten disease) is caused by deficiency of the soluble …

Movement disorders are a heterogeneous group of clinical syndromes in humans and
animals characterized by involuntary movements without changes in consciousness. Canine …

Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a progressive neurodegenerative
disease that results in early-onset, severe, progressive, neurological disabilities, leading to …

Using a canine model of classical late‐infantile neuronal ceroid lipofuscinosis (CLN2
disease), a study was conducted to evaluate the potential pharmacological activity of …

A recessive, adult-onset neuronal ceroid-lipofuscinosis (NCL) occurs in Tibetan terriers. A
genome-wide association study restricted this NCL locus to a 1.3 Mb region of canine …

Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an autosomal recessive condition
caused by variants in the TPP1 gene, leading to deficient activity of the lysosomal enzyme …