SUMMARY HIV-1 DNA persists in infected cells despite combined antiretroviral therapy
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …

HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency
establishment. We postulated a" block-and-lock" functional cure approach based on …

Among the different markers of HIV persistence in infected cells, total HIV DNA is to date the
most widely used. It allows an overall quantification of all viral forms of HIV DNA in infected …

Objectives To characterize viro-immunological outcomes following long-term combined
antiretroviral therapy (cART) initiated during primary HIV infection (PHI) or chronic HIV …

Quantification of human immunodeficiency virus type-1 (HIV-1) proviral DNA is increasingly
used to measure the HIV-1 cellular reservoirs, a helpful marker to evaluate the efficacy of …

Background Combination antiretroviral therapy (cART), the standard of care for HIV-1
infection, is considered to be successful when plasma viremia remains below the detection …

Cellular human immunodeficiency virus type 1 (HIV-1) DNA may be considered a marker of
disease progression with significant predictive power, but published data on its correlation …

Following reverse transcription, HIV viral DNA is integrated into host cell genomes and
establishes a stable latent infection, which has posed a major obstacle for obtaining a cure …

Background Accurate quantification of total HIV-DNA and residual-viremia by sensitive
assays is extremely useful to optimize monitoring of ART-treated patients. Objectives To …

Brain-resident microglia and myeloid cells (perivascular macrophages) are important HIV
reservoirs in vivo, especially in the central nervous system (CNS). Despite antiretroviral …