Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

To commemorate the 50th anniversary of the Society of Toxicology, this special edition
article reviews the history and current scope of xenobiotic metabolism and transport, with …

Induction of drug metabolism was described more than 40 years ago. Progress in
understanding the molecular mechanism of induction of drug-metabolizing enzymes was …

Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common
evolutionary history and having similar sequence features at the protein level. Selective …

Chemotherapy is one of the three most common treatment modalities for cancer. However,
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …

Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …

Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR)
are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the majority of …

The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for
both endogenous and exogenous stimuli by regulating the transcription of genes encoding …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

To gain insight on the expression of pregnane X receptor (PXR), we analyzed PXR. 1 and
PXR alternatively spliced transcripts in a panel of 36 human tissues. PXR. 1 was expressed …