Metalloporphyrins are efficient biomimetic models of heme enzymes such as cytochrome
P450 and peroxidases. They are also endowed with high affinity for double-stranded and G …

Background The interaction of small molecules with G quadruplexes is in focus due to its
role in molecular recognition and therapeutic drug design. Stabilization of G-quadruplex …

Targeting multiple malignancy features such as angiogenesis, proliferation and metastasis
with one molecule is an effective strategy in developing potent anticancer agents …

Arene Ru (II) complexes have long been extensively studied as potential inhibitors against
the proliferation of tumor cells, but their behavior against the migration and invasion of tumor …

Abstract Structure-activity relationship (SAR) studies have led to significant improvement in
desirable biological activity in different classes of molecules. A general consensus about the …

DNA-binding agents have been considered as an established opportunity for the
development of anticancer drugs and DNA fluorescence probes. This work reported the …

The [Cu (L) Cl2] 2 and [Pt (L) Cl2] complexes were prepared from the simple Schiff-base
ligand (E)-phenyl-N-((pyridin-2-yl) methylene) methanamine (L) and respectively, CuCl2 …

The direct binding of antiviral agents; Daclatasvir and valacyclovir and green synthesized
nanoparticles to salmon sperm DNA have been assessed in a comparative study. The …

Several ligands can bind to the non-canonical G-quadruplex DNA structures thereby
stabilizing them. These molecules can act as effective anticancer agents by stabilizing the …

Cancer is a leading cause of death, so continuous efforts into cancer therapy are imperative.
In tumor cells, telomerase and oncogene activity are key points for uncontrolled cell growth …