Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …

Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides
an unproven approach to cancer therapy with a strong biological rationale. FASN …

Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation
through its conversion into palmitoyl coenzyme A. Although palmitoylation affects many …

Re-programming of metabolic pathways is a hallmark of physiological changes in cancer
cells. The expression of certain genes that directly control the rate of key metabolic pathways …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Ovarian cancer is one of the most malignant gynecological cancers around the world. In
spite of multiple treatment options, the five-year survival rate is still very low. Several …

Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading
cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent …

Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the
increase in energy demand, cell division, and growth and successfully adapt to challenging …

Kaempferol is a flavonoid present in Kaempferia galanga and Opuntia ficus indica var.
saboten. Recent studies have suggested that it has anti-oxidant, anti-inflammatory, anti …