Basal ganglia calcifications could be incidental findings up to 20% of asymptomatic patients
undergoing CT or MRI scan. The presence of neuropsychiatric symptoms associated with …

Primary familial brain calcification (PFBC), also known as Fahr's disease, is a rare inherited
disorder characterized by bilateral calcification in the basal ganglia according to …

Brain calcification is a critical aging-associated pathology and can cause multifaceted
neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier …

Aging is recognized as the key risk factor for Alzheimer's disease (AD). This study aimed to
identify and verify potential aging-related genes associated with AD using bioinformatics …

Early-onset parkinsonism (EO parkinsonism), defined as subjects with disease onset before
the age of 40 or 50 years, can be the main clinical presentation of a variety of conditions that …

Primary familial brain calcification is a monogenic disease characterized by bilateral
calcifications in the basal ganglia and other brain regions, and commonly presents motor …

Primary familial brain calcification (PFBC) is an inherited neurodegenerative disorder mainly
characterized by progressive calcium deposition bilaterally in the brain, accompanied by …

Arterial calcification is a common phenomenon in the elderly, in patients with atherosclerosis
or renal failure and in diabetes. However, when present in very young individuals, it is likely …

Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble
inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it …

Microglia participate in central nervous system (CNS) development and homeostasis and
are often implicated in modulating disease processes. However, less is known about the …