Transitioning organic synthesis from organic solvents to water. What's your E Factor?

BH Lipshutz, S Ghorai - Green Chemistry, 2014 - pubs.rsc.org
Traditional organic chemistry, and organic synthesis in particular, relies heavily on organic
solvents, as most reactions involve organic substrates and catalysts that tend to be water …

Micellar catalysis as a tool for C–H bond functionalization toward C–C bond formation

E Borrego, A Caballero, PJ Pérez - Organometallics, 2022 - ACS Publications
Micelles generated upon dissolving surfactants in water can be employed as nanovessels
for catalytic transformations, in the so-called micellar catalysis methodology. This review is …

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System

Y Gu, Z Zhang, YE Wang, Z Dai, Y Yuan… - The Journal of …, 2021 - ACS Publications
Chemoselective deprotonative functionalization of benzylic C–H bonds is challenging,
because the arene ring contains multiple aromatic C (sp2)–H bonds, which can be …

Micellar system in copper-catalysed hydroxylation of arylboronic acids: facile access to phenols

K Inamoto, K Nozawa, M Yonemoto… - Chemical …, 2011 - pubs.rsc.org
Micellar system in copper-catalysed hydroxylation of arylboronic acids: facile access to phenols -
Chemical Communications (RSC Publishing) DOI:10.1039/C1CC14974A Royal Society of …

Rh (III)-catalyzed C–H activation/cyclization of benzamides and diazo compounds to form isocoumarins and α-pyrones

XG Li, M Sun, K Liu, Q Jin, PN Liu - Chemical Communications, 2015 - pubs.rsc.org
Rhodium-catalyzed intermolecular cyclization of benzamides and diazo compounds via C–
H activation has been achieved to construct C–C/C–O bonds for the first time. The process …

α-Arylation of (hetero) aryl ketones in aqueous surfactant media

AB Wood, DE Roa, F Gallou, BH Lipshutz - Green chemistry, 2021 - pubs.rsc.org
α-Arylation reactions can be performed in water, enabled by a designer surfactant, under
mild conditions and in the absence of organic co-solvents. A multitude of aryl and heteroaryl …

Synthesis of isocoumarins from cyclic 2-diazo-1, 3-diketones and benzoic acids via Rh (III)-Catalyzed C–H activation and esterification

C Yang, X He, L Zhang, G Han, Y Zuo… - The Journal of Organic …, 2017 - ACS Publications
A mild and efficient Rh (III)-catalyzed C–H activation/esterification reaction for the synthesis
of isocoumarins has been developed. This procedure uses readily available benzoic acids …

Selective oxymetalation of terminal alkynes via 6-endo cyclization: mechanistic investigation and application to the efficient synthesis of 4-substituted isocoumarins

Y Kita, T Yata, Y Nishimoto, K Chiba, M Yasuda - Chemical Science, 2018 - pubs.rsc.org
The cyclization of heteroatom-containing alkynes with π acidic metal salts is an attractive
method to prepare heterocycles because the starting materials are readily available and the …

NHC-catalyzed dual Stetter reaction: a mild cascade annulation for the syntheses of naphthoquinones, isoflavanones, and sugar-based chiral analogues

RN Mitra, K Show, D Barman, S Sarkar… - The Journal of Organic …, 2018 - ACS Publications
The N-heterocycle carbene (NHC)-catalyzed dual Stetter cascade reaction is discovered
through coupling of β-nitrostyrene with phthalaldehyde under mild conditions to furnish …

Zheda‐Phos for General α‐Monoarylation of Acetone with Aryl Chlorides

P Li, B Lü, C Fu, S Ma - Advanced Synthesis & Catalysis, 2013 - Wiley Online Library
A new, readily available, and air‐stable monophosphine ligand, ie, Zheda‐Phos, has been
developed for the general and highly effective palladium‐catalyzed monoarylation of …