Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …

The review focuses on mechanistic evidence for the link between obesity and breast cancer.
According to the IARC study, there is sufficient evidence that obesity is closely related to a …

Importance There has been little consideration of genomic risk of recurrence by breast
cancer subtype despite evidence of racial disparities in breast cancer outcomes. Objective …

Despite landmark advances in cancer treatments over the last 20 years, cancer remains the
second highest cause of death worldwide, much ascribed to intrinsic and acquired …

Insulin-like growth factor binding proteins (IGFBPs) and the associated signaling
components in the insulin-like growth factor (IGF) pathway regulate cell differentiation …

Despite decades of research presenting insulin-like growth factor-1 receptor (IGF1R) as an
attractive target for cancer therapy, IGF1R inhibitors ultimately failed in clinical trials. This …

Background Difference in pathologic complete response (pCR) rate after neoadjuvant
chemotherapy does not capture the impact of treatment on downstaging of residual cancer …

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity.
Emerging novel drugs aim to regulate the anti-tumor immune response by activating innate …

There has been a long-standing interest in targeting the type 1 insulin-like growth factor
receptor (IGF-1R) signaling system in breast cancer due to its key role in neoplastic …

Aim Metformin is used for the management of type 2 diabetes mellitus (T2DM) and is being
tested clinically as an anticancer agent. Metformin concentrations safely achievable in …