Single‐cell mass spectrometry approaches to explore cellular heterogeneity

L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Role of DNA methyl-CpG-binding protein MeCP2 in Rett syndrome pathobiology and mechanism of disease

S Pejhan, M Rastegar - Biomolecules, 2021 - mdpi.com
Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with
patients displaying neurological regression and autism spectrum features. The affected …

Transcriptional and translational differences of microglia from male and female brains

D Guneykaya, A Ivanov, DP Hernandez, V Haage… - Cell reports, 2018 - cell.com
Sex differences in brain structure and function are of substantial scientific interest because of
sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a …

SARS-CoV-2 receptors and entry genes are expressed in the human olfactory neuroepithelium and brain

L Fodoulian, J Tuberosa, D Rossier, M Boillat, C Kan… - Iscience, 2020 - cell.com
Reports indicate an association between COVID-19 and anosmia, as well as the presence
of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium …

Polyploidy, the nucleotype, and novelty: the impact of genome doubling on the biology of the cell

JJ Doyle, JE Coate - International Journal of Plant Sciences, 2019 - journals.uchicago.edu
Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Insulin-like growth factor-1 supplementation promotes brain maturation in preterm pigs

LI Christiansen, B Holmqvist, X Pan, K Holgersen… - eneuro, 2023 - eneuro.org
Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is
associated with postnatal growth restriction and poor neurologic outcomes. It remains …

Poor transcript‐protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause

CP Moritz, T Mühlhaus, S Tenzer… - Journal of …, 2019 - Wiley Online Library
Transcription, translation, and turnover of transcripts and proteins are essential for cellular
function. The contribution of those factors to protein levels is under debate, as transcript …

Epigenetic control of cyp19a1a expression is critical for high temperature induced Nile tilapia masculinization

YY Wang, LX Sun, JJ Zhu, Y Zhao, H Wang… - Journal of Thermal …, 2017 - Elsevier
In fish species with temperature-dependent sex determination (TSD) or genotypic sex
determination plus temperature effects (GSD+ TE), temperature can either affect sex …

The MeCP2E1/E2-BDNF-miR132 Homeostasis Regulatory Network Is Region-Dependent in the Human Brain and Is Impaired in Rett Syndrome Patients

S Pejhan, MR Del Bigio, M Rastegar - Frontiers in Cell and …, 2020 - frontiersin.org
Rett Syndrome (RTT) is a rare and progressive neurodevelopmental disorder that is caused
by de novo mutations in the X-linked Methyl CpG binding protein 2 (MECP2) gene and is …

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

A Bezawork-Geleta, H Wen, LF Dong, B Yan… - Nature …, 2018 - nature.com
Cell growth and survival depend on a delicate balance between energy production and
synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial …