Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

G Caruso, SA Torrisi, MP Mogavero, W Currenti… - Pharmacology & …, 2022 - Elsevier
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century

WH Lee, CY Loo, M Bebawy, F Luk… - Current …, 2013 - ingentaconnect.com
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention

WY Huang, YZ Cai, Y Zhang - Nutrition and cancer, 2009 - Taylor & Francis
Natural phenolic compounds play an important role in cancer prevention and treatment.
Phenolic compounds from medicinal herbs and dietary plants include phenolic acids …

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

R Wilken, MS Veena, MB Wang, ES Srivatsan - Molecular cancer, 2011 - Springer
Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant,
commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine …

Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

A Mohammadi, CN Blesso, GE Barreto… - The Journal of nutritional …, 2019 - Elsevier
Monocytes and macrophages are important cells of the innate immune system that have
diverse functions, including defense against invading pathogens, removal of dead cells by …

[HTML][HTML] An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury

X Gao, Z Han, C Huang, H Lei, G Li, L Chen, D Feng… - Bioactive materials, 2022 - Elsevier
Spinal cord regeneration after a spinal cord injury (SCI) remains a difficult challenge due to
the complicated inflammatory microenvironment and neuronal damage at the injury sites. In …

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

M Mohajeri, A Sahebkar - Critical reviews in oncology/hematology, 2018 - Elsevier
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin

A Barzegar, AA Moosavi-Movahedi - PloS one, 2011 - journals.plos.org
Curcumin has many pharmaceutical applications, many of which arise from its potent
antioxidant properties. The present research examined the antioxidant activities of curcumin …

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

A Cianciulli, R Calvello, C Porro, T Trotta… - International …, 2016 - Elsevier
Microglia are resident macrophages in the central nervous system (CNS) deputed to defend
against pathogens. Persistent or acute inflammation of microglia leads to CNS disorders, so …

Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

M Garcia‐Alloza, LA Borrelli, A Rozkalne… - Journal of …, 2007 - Wiley Online Library
Alzheimer's disease (AD) is characterized by senile plaques and neurodegeneration
although the neurotoxic mechanisms have not been completely elucidated. It is clear that …