Apoptosis has been established as a mechanism of anti-cancer defense. Members of the
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that
restore the normal apoptotic pathways have the potential for effectively treating cancers that …

Physicians are often asked to make prognostic assessments but often worry that their
assessments will prove inaccurate. Prognostic systems were developed to enhance the …

Defects in apoptosis signaling pathways are common in cancer cells. Such defects may play
an important role in tumor initiation because apoptosis normally eliminates cells with …

Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-
regulation of the balance between proliferation and apoptosis contributes to tumor initiation …

The choice of study population needs to be carefully considered for studies of markers of
potential prognostic importance. Many published studies include patients with all Dukes' …

There is an increasing demand for biomarkers in colon cancer for risk assessment, early
detection, prognosis, and surrogate end points. A number of biomarkers have been …

The products of bcl‐2 and p53 genes are involved in the regulation of apoptosis and
proliferation and have been associated with prognosis in several malignancies, including …

Publisher Summary This chapter focuses on the current state of knowledge regarding the
mechanisms by which programmed cell death (PCD) is triggered by cancer …

Multiple intracellular signaling pathways, such as Wnt/β-catenin signaling, epidermal growth
factor receptor/Ras signaling, and p53 signaling are frequently dysregulated in colorectal …