The treatment of multiple sclerosis has been transformed by the successful development of
immunotherapies that efficiently reduce disease activity and related clinical relapses during …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …

Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated
from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Background Multiple sclerosis is a degenerative inflammatory disease of the CNS
characterised by immune-mediated destruction of myelin and progressive neuroaxonal loss …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Age-associated decline in regeneration capacity limits the restoration of nervous system
functionality after injury. In a model for demyelination, we found that old mice fail to resolve …

Metabolomics, in which small-molecule metabolites (the metabolome) are identified and
quantified, is broadly acknowledged to be the omics discipline that is closest to the …