Despite many decades of intensive studies of Yersinia pestis, the causative agent of plague,
there is no safe and efficient vaccine against this devastating disease. A recently developed …

The causative organism of plague is the bacterium Yersinia pestis. Advances in
understanding the complex pathogenesis of plague infection have led to the identification of …

Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its
causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror …

Pneumonic plague is one of the world's most deadly infectious diseases. The causative
bacterium, Yersinia pestis, has the potential to be exploited as a biological weapon, and no …

The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which
poses both a natural and adversarial threat. Due largely to the rapid course and high …

Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if
left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however …

Vaccination can significantly reduce worldwide morbidity and mortality to infectious
diseases, thereby reducing the health burden as a result of microbial infections. Effective …

The importance attached to rapidly developing our biodefensive capabilities has recently
resulted in a significantly increased funding for biodefense research. Accordingly …

It is of great interest to develop a pneumonic plague vaccine that would induce combined
humoral and cellular immunity in the lung. Here we investigate a novel approach based on …

Septic pneumonias resulting from bacterial infections of the lung are a leading cause of
human death worldwide. Little is known about the capacity of CD8 T cell-mediated immunity …