The past, present and future of anti-malarial medicines

EG Tse, M Korsik, MH Todd - Malaria journal, 2019 - Springer
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Artemisinin action and resistance in Plasmodium falciparum

L Tilley, J Straimer, NF Gnädig, SA Ralph… - Trends in …, 2016 - cell.com
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

MI Veiga, SK Dhingra, PP Henrich, J Straimer… - Nature …, 2016 - nature.com
Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …

Malarial hemozoin: from target to tool

LM Coronado, CT Nadovich, C Spadafora - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Malaria is an extremely devastating disease that continues to affect millions of
people each year. A distinctive attribute of malaria infected red blood cells is the presence of …

Clinical guide and update on porphyrias

U Stölzel, MO Doss, D Schuppan - Gastroenterology, 2019 - Elsevier
Physicians should be aware of porphyrias, which could be responsible for unexplained
gastrointestinal, neurologic, or skin disorders. Despite their relative rarity and complexity …

[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

FA Siddiqui, X Liang, L Cui - … Journal for Parasitology: Drugs and Drug …, 2021 - Elsevier
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

Resistance to artemisinin combination therapies (ACTs): do not forget the partner drug!

C Nsanzabana - Tropical medicine and infectious disease, 2019 - mdpi.com
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

Heme detoxification in the malaria parasite: A target for antimalarial drug development

KA de Villiers, TJ Egan - Accounts of chemical research, 2021 - ACS Publications
Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …