Interplay between group A Streptococcus and host innate immune responses
MSW Su, YL Cheng, YS Lin, JJ Wu - Microbiology and Molecular …, 2024 - Am Soc Microbiol
SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …
clinically well-adapted human pathogen that harbors rich virulence determinants …
Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage
H Yin, Z Zhao, Y Yan, Y Yuan, W Qu, H Wang, C Zhu… - Mbio, 2024 - journals.asm.org
Members of the gasdermin (GSDM) family are critical for inducing programmable pyroptosis
by forming pores on the cell membrane. GSDMB, GSDMC, GSDMD, and GSDME are …
by forming pores on the cell membrane. GSDMB, GSDMC, GSDMD, and GSDME are …
Group A Streptococcus infection of the nasopharynx requires proinflammatory signaling through the interleukin-1 receptor
ABSTRACT Group A Streptococcus (GAS) is the etiologic agent of numerous high-morbidity
and high-mortality diseases. Infections are typically highly proinflammatory. During the …
and high-mortality diseases. Infections are typically highly proinflammatory. During the …
Detoxification of reactive oxygen species by the hyaluronic acid capsule of group A Streptococcus
S Wilde, A Dash, A Johnson, K Mackey… - Infection and …, 2023 - Am Soc Microbiol
The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …
Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD+-Glycohydrolase: Evidence for Extracellular Activity
D Hancz, E Westerlund, B Bastiat-Sempe, O Sharma… - MBio, 2017 - Am Soc Microbiol
ABSTRACT Group A Streptococcus (GAS) is a common human pathogen and the etiologic
agent of a large number of diseases ranging from mild, self-limiting infections to invasive life …
agent of a large number of diseases ranging from mild, self-limiting infections to invasive life …
Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage
ABSTRACT Group A Streptococcus (GAS) is a human-adapted pathogen responsible for a
variety of diseases. The GAS M1UK lineage has contributed significantly to the recently …
variety of diseases. The GAS M1UK lineage has contributed significantly to the recently …
Assessing interleukin-1β activation during pyroptosis
The cytokine interleukin-1β (IL-1β) is a major mediator of inflammation in autoinflammatory
disease and the host response to infection. IL-1β is stored within cells in an inert form, which …
disease and the host response to infection. IL-1β is stored within cells in an inert form, which …
[图书][B] Inflammasomes: clinical and therapeutic implications
MD Cordero, E Alcocer-Gómez - 2018 - Springer
Infiammasomes are multiprotein complexes formed and activated after exposure to
pathogenic microbes and host danger signals that control the maturation and production of …
pathogenic microbes and host danger signals that control the maturation and production of …
Inhibiting inflammasomes with small molecules
AAB Robertson - Inflammasomes: Clinical and Therapeutic Implications, 2018 - Springer
Modulation of inflammasomes has tremendous therapeutic potential and is hotly pursued by
industry and academia alike. Indeed a growing number of patents are emerging to protect …
industry and academia alike. Indeed a growing number of patents are emerging to protect …
Detection of Inflammasome Activation in Murine Bone Marrow-Derived Macrophages Infected with Group A Streptococcus
C Valfridsson, E Westerlund, D Hancz… - … : Methods and Protocols, 2023 - Springer
Inflammasomes are large multiprotein complexes that assemble mainly in innate immune
cells after detection of microbial or sterile insults. Activation of inflammasomes is a key …
cells after detection of microbial or sterile insults. Activation of inflammasomes is a key …