Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a
metazoan existence. All members of the integrin family adopt a shape that resembles a large …

Background Cells sense the extracellular environment using adhesion receptors (integrins)
linked to the intracellular actin cytoskeleton through a complex network of regulatory …

Integrins require an activation step prior to ligand binding and signaling. How talin and
kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we …

Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array …

Living cells are exquisitely responsive to mechanical cues, yet how cells produce and detect
mechanical force remains poorly understood due to a lack of methods that visualize cell …

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required
for penetration through the basement membrane, stromal invasion and intravasation …

We show that the three conformational states of integrin α5β1 have discrete free energies
and define activation by measuring intrinsic affinities for ligand of each state and the …

Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis.
Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are …

Whether β1 integrin ectodomains visit conformational states similarly to β2 and β3 integrins
has not been characterized. Furthermore, despite a wealth of activating and inhibitory …