Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …

Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp)
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

Novel metabolites distinct from canonical pathways can be identified through the integration
of three cheminformatics tools: BinVestigate, which queries the BinBase gas …

Metabolomics, in which small-molecule metabolites (the metabolome) are identified and
quantified, is broadly acknowledged to be the omics discipline that is closest to the …

The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …