Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a
remarkably broad spectrum of biologic activities. MTs act as inhibitors of the self-assembly …

Abstract Purpose of Review Transthyretin (TTR)-related cardiac amyloidosis is a progressive
infiltrative cardiomyopathy that mimics hypertensive, hypertrophic heart disease and may go …

Objective This study aims to report the genotypes and phenotypes of hereditary transthyretin
amyloidosis (ATTR) in a large Chinese cohort, yet the clinical and genetic profiles of ATTR …

The complement system is a key component of innate immunity since it plays a critical role in
inflammation and defense against common pathogens. However, an inappropriate …

Parkinson's disease (PD) is a neurodegenerative disease with an impairment of movement
execution that is related to age and genetic and environmental factors. 1-methyl-4-phenyl-1 …

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy
develops in patients with various diseases, including rare familial or acquired amyloid …

The misfolding of normally soluble proteins causes their aggregation and deposition in the
tissues which disrupts the normal structure and function of the corresponding organs. The …

Abstract Objective Hereditary amyloid transthyretin (ATTRv) amyloidosis with
polyneuropathy, a rare autosomal‐dominant disease, has gained attention in recent years …

Introduction Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) remains
a diagnostic challenge due to clinical, neurophysiological, and laboratory findings …

Background and objectives To examine the efficacy and safety of patisiran, an RNA
interference therapeutic, in patients from Taiwan with hereditary transthyretin-mediated …