MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells

S Perrin, S Protic, V Bretegnier, I Laurendeau… - Science Translational …, 2024 - science.org
Congenital pseudarthrosis of the tibia (CPT) is a severe pathology marked by spontaneous
bone fractures that fail to heal, leading to fibrous nonunion. Half of patients with CPT are …

[HTML][HTML] Congenital pseudoarthrosis of the tibia: a narrative review

H Banchhor, V Chimurkar - Cureus, 2022 - ncbi.nlm.nih.gov
Congenital pseudoarthrosis of the tibia, also known as CPT, is a rare bone disease mostly
occurring in the pediatric age group of 10. The case generally represents anterolateral …

Preventing of nonunion in congenital pseudarthrosis of the tibia cases of Crawford Type I and II through the use of allograft bypass and a brace: Midterm findings

C Dong, C Li, U Brückner… - Journal of Children's …, 2024 - journals.sagepub.com
Background: Congenital pseudarthrosis of the tibia is a limb deformity, which can be
distressing for the affected patients and the pediatric orthopedic surgeons involved. We …

Unraveling the Molecular Landscape of Congenital Pseudoarthrosis of the Tibia: Insights from a Comprehensive Analysis of 162 Probands

G Zhu, N Li, Y Zheng, S Wang, G Yang, Y Liu, Z Xu… - medRxiv, 2023 - medrxiv.org
Congenital pseudarthrosis of the tibia (CPT, HP: 0009736), commonly known as bowing of
the tibia, is a rare congenital tibia malformation characterized by spontaneous tibial fractures …

[HTML][HTML] A good index surgery for congenital pseudarthrosis of the tibia minimizes complications following surgery

SHS Tan, Y Pei, CX Chan, KC Pang… - Bone & Joint …, 2024 - pmc.ncbi.nlm.nih.gov
Aims Congenital pseudarthrosis of the tibia (CPT) has traditionally been a difficult condition
to treat, with high complication rates, including nonunion, refractures, malalignment, and leg …

Persistent Congenital Tibial Pseudoarthrosis until Adulthood Treated with Vascularised Fibular Graft: A 17-year Follow-up

S Suwannaphisit, K Kawamura… - Journal of Plastic and …, 2025 - jstage.jst.go.jp
A 39-year-old woman diagnosed with persistent congenital tibial pseudoarthrosis until
adulthood presented with a right leg angular deformity, associated pain, and significant limb …

Anterolateral congenital tibial bowing: case report

G Mastantuoni, AG Aulisa, M Giordano… - Frontiers in …, 2023 - frontiersin.org
Background The treatment of congenital curvatures (bowing) of the tibia still represents a
challenging problem for all pediatric orthopedic surgeons because of its unpredictable …

Reconstructive surgery in the treatment of congenital pseudarthrosis of the tibia in children using microsurgical techniques: Reconstruction or amputation?

EA Zakharyan, NG Chigvariya… - Pediatric …, 2022 - journals.eco-vector.com
BACKGROUND: Numerous methods are available for the treatment of congenital
pseudarthrosis of the tibia, but none of them offers a 100% satisfactory result and does not …

[PDF][PDF] Возможности реконструктивной хирургии конечностей при лечении врожденного ложного сустава костей голени у детей с применением …

ЕА Захарьян, НГ Чигвария… - Ортопедия …, 2022 - researchgate.net
Результаты. Средний возраст пациентов—7, 8±2, 2 года. Преобладали мальчики, и в
60% случаев выявлен нейрофиброматоз I типа. Средняя величина дефекта составила …

Congenital Pseudoarthrosis of the Tibia: A Narrative Review

B Hansika, C Vilas - Cureus, 2022 - search.proquest.com
Congenital pseudoarthrosis of the tibia, also known as CPT, is a rare bone disease mostly
occurring in the pediatric age group of 10. The case generally represents anterolateral …