Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …

Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …

As currently postulated, a complex treatment may be key to an effective therapy for
Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a …

An acid-mediated and DMSO participant one-pot tandem synthesis of 3-substituted-1-aryl-1
H-pyrazolo-[3, 4-b] quinoline from readily available anilines and pyrazolones was achieved …

A facile, swift and ecofriendly microwave-assisted multi-component/one-pot protocol is
designed for the synthesis of novel pyrazolo-[3, 4-b]-quinolines at ambient temperature in …

A simple and efficient Ru (II)-catalyzed transfer hydro-dehalogenation of organic halides
using 2-propanol solvent as the hydride source was reported. This methodology is …

Introduction: The translocator protein (TSPO) is an emerging target in diverse
neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) …

A series of novel alkyl amide functionalized 2, 3-pyrazole fused quinoline derivatives 5, 6
and 7 have been prepared starting from quinoline-2 (1H) one 1 in a series of steps. All the …

This paper summarises a little over 100 years of research on the synthesis and the
photophysical and biological properties of 1 H-pyrazolo [3, 4-b] quinolines that was …

Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically
active derivatives. Thus, we developed new quinoline derivatives and investigated them as …