The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy
delivery in the clinic. Viral vectors, however, have certain issues involving genome …

An improved understanding of the cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …

Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

Cancer is a genetic disease originating from the accumulation of gene mutations in a
cellular subpopulation. Although many therapeutic approaches have been developed to …

Over a decade ago, a landmark study that reported derivation of induced Pluripotent Stem
Cells (iPSCs) by reprogramming fibroblasts has transformed stem cell research attracting …

Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …

The ability to produce extremely small and circular supercoiled vectors has opened new
territory for improving non-viral gene therapy vectors. In this work, we compared transfection …