We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that
affect approximately half of people living with HIV (PLWH) despite effective antiretroviral …

Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due
to advancements in both prevention and treatment of HIV. However, major challenges still …

Aims To estimate whether opioid substitution treatment (OST) with buprenorphine or
methadone is associated with a greater reduction in the risk of all‐cause mortality (ACM) …

Background Opioid agonist treatment (OAT) reduces many of the harms associated with
opioid dependence. We use mathematical modelling to comprehensively evaluate the …

Aims To examine the cost‐effectiveness of hepatitis C virus (HCV) treatment of people who
inject drugs (PWID), combined with medication‐assisted treatment (MAT) and syringe …

With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …

Background The initiation and cessation of opioid agonist treatment (OAT) have both been
associated with elevated risk of fatal overdose. We examined risk of non-fatal overdose …

Background Stimulants, such as amphetamines and cocaine, are widely injected among
people who inject drugs (PWID). Systematic reviews indicate stimulant injection is …

Background Most new HIV infections among people who inject drugs (PWID) in eastern
Europe and central Asia occur in Russia, where PWID have a high risk of overdose. In …