Fragile X mental retardation protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: a pilot study

JR Brašić, JA Goodman, A Nandi, DS Russell… - Brain Sciences, 2022 - mdpi.com
Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein
(FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) in …

Adaptive, behavioral, and cognitive outcomes in individuals with fragile X syndrome with varying autism severity

R Aishworiya, YE Tak, MD Ponzini… - International Journal …, 2023 - Wiley Online Library
This study aimed to determine the association between severity of autism spectrum disorder
(ASD) and cognitive, behavioral, and molecular measures in individuals with fragile X …

Peptidomimetics design and characterization: Bridging experimental and computer-based approaches.

A Romagnoli, J Rexha, N Perta… - Progress in Molecular …, 2024 - iris.uniroma1.it
Peptidomimetics, designed to mimic peptide biological activity with more drug-like
properties, are increasingly pivotal in medicinal chemistry. They offer enhanced systemic …

Role of Fragile X Ribonucleoprotein and Brain-Derived Neurotrophic Factor in Presynaptic Local Translation Regulation and Synaptic Plasticity

SC Kharod - 2024 - search.proquest.com
Protein synthesis is crucial for solidifying long-term memories, likely by fine tuning synaptic
changes. Recent findings indicate that disruptions in synaptic protein synthesis may serve …

[PDF][PDF] Insensitivity to anorexigenic effects of naltrexone in the VPA rat model of autism

JE Bray - 2022 - researchcommons.waikato.ac.nz
Autism spectrum disorder (ASD) is a complex disorder whose etiology lies in, among others,
abnormal neural processing, and improper neural circuitry development. This results in a …