[HTML][HTML] Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis

KA Williams, YS Roh, I Brown, N Sutaria… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by
intensely pruritic, hyperkeratotic nodules distributed on the trunk and extensor surfaces of …

[HTML][HTML] Phase 3 trial of nemolizumab in patients with prurigo nodularis

SG Kwatra, G Yosipovitch, FJ Legat… - … England Journal of …, 2023 - Mass Medical Soc
Background Prurigo nodularis is a chronic, debilitating, and severely pruritic
neuroimmunologic skin disease. Nemolizumab, an interleukin-31 receptor alpha antagonist …

[HTML][HTML] Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials

G Yosipovitch, N Mollanazar, S Ständer, SG Kwatra… - Nature medicine, 2023 - nature.com
Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules.
The LIBERTY-PN PRIME and PRIME2 phase 3 trials enrolled adults with PN with≥ 20 …

[HTML][HTML] Trial of nemolizumab in moderate-to-severe prurigo nodularis

S Ständer, G Yosipovitch, FJ Legat… - … England Journal of …, 2020 - Mass Medical Soc
Background Prurigo nodularis is a chronic pruritic skin disease with multiple nodular skin
lesions. Nemolizumab is a monoclonal antibody targeting the interleukin-31 receptor, which …

Prurigo nodularis: epidemiology and clinical features

AH Huang, KA Williams, SG Kwatra - Journal of the American Academy of …, 2020 - Elsevier
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely
pruritic, hyperkeratotic nodules that favor the extensor surfaces of the extremities and the …

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus

S Elmariah, B Kim, T Berger, S Chisolm… - Journal of the American …, 2021 - Elsevier
Background Prurigo nodularis (PN) is a chronic disease characterized by intensely pruritic,
raised, nodular lesions. Because there are currently no United States Food and Drug …

[HTML][HTML] Pruritus as a distinctive feature of type 2 inflammation

S Garcovich, M Maurelli, P Gisondi, K Peris… - Vaccines, 2021 - mdpi.com
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic.
Pruritus might have a tremendous impact on patients' quality of life and strongly interfere …

[HTML][HTML] Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization

M Belzberg, MP Alphonse, I Brown, KA Williams… - Journal of Investigative …, 2021 - Elsevier
Prurigo nodularis (PN) is an understudied, chronic inflammatory skin disease that
disproportionately affects African Americans and presents with intensely pruritic nodules of …