Infiltration of macrophages in and around tumor nest represents one of the most crucial
hallmarks during tumor progression. The mutual interactions with tumor cells and stromal …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Tumor-associated macrophages (TAM) are prominent components of tumor
microenvironment (TME) and capable of promoting cancer progression. However, the …

The tumour microenvironment (TME) is composed of extracellular matrix and non-mutated
cells supporting tumour growth and development. Tumour-associated macrophages (TAMs) …

Cardiovascular disease is the leading cause of mortality and morbidity around the globe,
creating a substantial socio-economic burden as a result. Myocardial infarction is a …

Macrophages are present in all vertebrate tissues and have emerged as multifarious cells
with complex roles in development, tissue homeostasis, and disease. Macrophages are a …

Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how
TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains …